The International Conference on Sustainable Intelligent Systems and Next-Gen Computing aims to provide a high-quality international forum for researchers, academicians, industry professionals, and innovators to present original and unpublished research addressing the design, development, and deployment of intelligent and next-generation computing systems with a strong emphasis on sustainability, security, and human-centricity. The conference covers theoretical foundations, algorithmic advances, system architectures, and real-world applications in areas such as artificial intelligence and machine learning, Internet of Things, blockchain technologies, cybersecurity, green and energy-efficient computing, Industry 5.0, smart cities, digital healthcare, and smart manufacturing. In addition to core research tracks, the conference features a dedicated Industry Track / Case Study Track that encourages applied research, industrial case studies, prototypes, deployment experiences, and solution-driven contributions from corporate R&D labs, startups, and technology practitioners. The conference also promotes industry partnerships and sponsorship-supported engagement through technical sessions, invited industry talks, and collaborative forums, fostering meaningful interaction between academia and industry. The conference offers a rigorous peer-review process, opportunities for global visibility and networking, and the prospect of publication in Springer’s Lecture Notes in Computer Science (LNCS) series, ensuring wide dissemination, academic recognition, and practical impact of research contributions.